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Carnations Bouquet In A Vase. Tropical Basket. Say It With Chocolates. Make A Wish Deluxe. Stash of Snacks. In this regard, there is growing consensus that the current IGRA cutoff value requires reevaluation and borderline results need to be interpreted with prudence [16] , [49]. Quantitation of additional analytes in IGRA supernatants has been to shown to distinguish between active disease and Mtb infection in children [50]. In response to Mtb-specific antigens, high-risk children expressed significantly higher levels of CXCL10 and IL-2 than low-risk groups and the levels strongly correlated with Mtb exposure and grade of infectiousness of index cases.

In the present study, we found that by either lowering the IGRA cutoff value or by including the analysis of CXCL10 in the IGRA supernatants, sensitivity was enhanced but at the cost of compromising the specificity of the IGRA test and that we could obtain similar trade-offs by either strategy.

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Variability in repeat test results and poor specificity in certain populations where sensitivity to non-tuberculous mycobacteria is widespread [52] prompted modification of the initial 10 mm cutoff value for TST. Interpretation of the TST results now takes into account the clinical setting, with the current recommendation of 15 mm cutoff for low prevalence population and a 5 mm cutoff for high-risk population [53]. Similarly, there is growing consensus that IGRA cutoff of 0. Currently, there are a number of different recommendations for IGRA use [55].

Contacts of TB patients, particularly within the one year window following exposure, are at increased risk of developing TB [56]. Until such data are available, it may be important for screening programs to recommend retesting of individuals who are IGRA negative, particularly those who are recently exposed HHC.

Quantification of CXCL Browse Subject Areas? Click through the PLOS taxonomy to find articles in your field. Introduction Tuberculosis TB , caused by Mycobacterium tuberculosis Mtb , is still a major human health problem, especially in developing countries. Download: PPT. Figure 1. Pie charts show the number and percentage of HHC in each category.

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Figure 2. Table 2.



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Sensitivity and specificity using alternate cutoff values. Improving IGRA and TST concordance by using Menzies criterion for TST conversion To determine whether TST conversion was due to boosting, the data were also analyzed using the Menzies criterion which is designed to distinguish between true conversion and boosting [30] in the analysis.



Discussion Once IGRA became commercially available, numerous studies were conducted to determine the performance of the test, including sensitivity, specificity and accuracy. Supporting Information. Figure S1. Figure S2. Table S1. References 1. Clin Proteomics 8. View Article Google Scholar 3. Pulm Med View Article Google Scholar 4. Munoz L, Santin M Interferon-gamma release assays versus tuberculin skin test for targeting people for tuberculosis preventive treatment: an evidence-based review.

J Infect — View Article Google Scholar 5. PLoS One 8: e View Article Google Scholar 6. Clin Infect Dis — View Article Google Scholar 7. Eur J Pediatr — View Article Google Scholar 8.