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Select two study versions to compare. One each from columns A and B. Choose either the "Merged" or "Side-by-Side" comparison format to specify how the two study versions are to be displayed. The Side-by-Side format only applies to the Protocol section of the study. Click "Compare" to do the comparison and show the differences. Select a version's Submitted Date link to see a rendering of the study for that version. A yellow table row indicates the study version currently being viewed.

Hover over the " Recruitment Status " to see how the study's recruitment status changed. Study edits or deletions are displayed in red.

Study additions are displayed in green. Scroll up to access the controls. Oversight U. Study Description Brief Summary: This clinical trial is being conducted to learn more about a potential treatment valoctocogene roxaparvovec for people with severe hemophilia A. Only one dose of valoctocogene roxaparvovec is being given in this study, and this dose has been previously studied in another clinical trial in patients with hemophilia A. This is a phase 3 study which is meant to show that the study drug is safe and works to help treat hemophilia A.

The study will see if liver cells are able to make Factor VIII that functions properly after receiving this study drug. The study will also examine the effects that the study drug has on how much Factor VIII concentrates patients have to inject into their veins and on their bleeding episodes after the study drug has been administered. Finally, the study will see if and how the body responds to the study drug - for example, whether liver cells become inflamed or whether the body makes antibodies something the immune system makes to protect itself against things like bacteria and viruses against the vector or the new Factor VIII gene.

Detailed Description:. Outcome Measures Primary Outcome Measures: 1.

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Haemo-QoL-A is a hemophilia-specific, health-related quality of life questionnaire for adults on a scale of with the lower value representing a better outcome [Time Frame: 52 weeks] 5. Individuals with signs and symptoms suggestive of TB should be further evaluated for TB disease, whereas those without these symptoms should be started on IPT.

Lack of monitoring of the implementation of CTXp and IPT was another reported constraint to scale-up of these interventions, a limitation that highlights an urgent need.

Consequently, indicators that measure CTXp and IPT prescription should be included in systems to monitor patients with HIV in order to record progress in implementation. Patients diagnosed with relatively early HIV infection are often lost to clinical care only to re-enter the medical care system later, when their disease is advanced. Both treatments can prevent opportunistic infections among people living with HIV, improve their quality of life and improve rates of retention in HIV care.

These benefits may facilitate regular monitoring of these patients and timely initiation of ART when needed.

Operational aspects of CTXp and IPT are similar and the beneficiary population overlaps; consequently the possibility of co-packaging or co-formulating CTX and isoniazid might be explored to address issues related to logistics, adherence and integration of services. Our study has a few limitations. First, we could not independently validate the data reported by in-country staff because we did not have access to the national reports.

Second, because existing national reports were the source of information for this survey, the results may not reflect recent progress at various facilities in the implementation of these policies.

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Strong advocacy and dissemination of evidence-based information regarding the benefits of CTXp and IPT are urgently required at the national and international level. IPT offers potential benefits in reducing morbidity, and CTXp offers potential benefits in reducing both morbidity and mortality among people living with HIV. Moreover, TB represents a potential threat to the significant health benefits achievable by scale-up of HIV care and treatment.

Health Topics. About Us. Wi-Fi connection is available. It offers air-conditioned rooms, room service and hour front desk service. The property is a modern, nonsmoking building with air-conditioned rooms. Friendly staff with good english, parking, decent breakfast and a little gym. The facility is amazing. And very clean.

Guests can enjoy a meal at the restaurant or a drink at the bar at the property. Free WiFi is also available. Bristol Easy Vitoria surpassed my expectations. I've never been so welcome.

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